COMBS, Andrew P.,SPARKS, Richard B.,MADUSKUIE, Thomas P.,RODGERS, James D.
申请号：
ES14721642
公开号：
ES2755827T3
申请日:
2014.03.14
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: --- represents a single bond or a double bond； L is CR9R9a, O, S, SO, or SO2； Cy1 is selected from phenyl or a 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein said phenyl or 5-6 membered heteroaryl of Cy1 is optionally substituted with 1, 2, 3 or 4 groups independently selected from R11； R1 and R2 are independently selected from H, halo, CN, OH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1- 6 haloalkyl, ORa1, SRa1, C (= O) Rb1, C (= O ) NRc1Rd1, C (= O) ORa1, OC (= O) Rb1, OC (= O) NRc1Rd1, NRc1Rd1, NRc1C (= O) Rb1, NRc1 C (= O) NRc1Rd1, NRc1 C (= O) ORa1, S (= O) Rb1, S (= O) NRc1Rd1, S (= O) 2Rb1, NRc1S (= O) 2Rb1 and S (= O) 2NRc1Rd1, wherein said C1-6 alkyl, C2-6 alkenyl and C2- 6 alkynyl of R1 and R2 are optionally substituted with 1, 2 or 3 groups independently selected from halo, CN, OH, ORa1, SRa1, C (= O) Rb1, C (= O) NRc1Rd1, C (= O) ORa1, OC (= O) Rb1, OC (= O) NRc1Rd1, NRc1Rd1, NRc1C (= O) Rb1, NRc1C (= O) NRc1Rd1, NRc1C (= O) ORa1, S (= O) Rb1, S (= O) NRc1Rd1 , S (= O) 2Rb1, NRc1S (= O) 2Rb1 and S (= O) 2NRc1R1； provided neither R1 nor R2 are Cl, Br, I, CN, OH or when L is O or S； alternatively, R1 and R2 together with the carbon atom to which they are attached combine to form a C3-7 cycloalkyl group, wherein said cycloalkyl group is optionally substituted with 1, 2, 3 or 4 groups independently selected from R20； Cy3 is selected from phenyl, C3-7 cycloalkyl, a 5-10 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-10 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, o, and S, wherein said phenyl, C3-7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 Cy3 heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 groups independently selected from R13, wherein a ring-forming nitrogen atom of said 5-
