Ronald Knegtel;David Bebbington;Pan Li;Hayley Marie Binch;Jean-Damien Charrier;Julian Marian Charles Golec
发明人:
Jean-Damien Charrier,Pan Li,Ronald Knegtel,Julian Marian Charles Golec,David Bebbington,Hayley Marie Binch
申请号：
US13094183
公开号：
US08633210B2
申请日:
2011.04.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention describes novel triazole compounds of formula IX:wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitrogen； G is Ring C or Ring D； Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1； Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl； Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring； R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
