ELLSWORTH, Bruce,SHI, Jun,EWING, William,JURICA, Elizabeth,HERNANDEZ, Andres,WU, Ximao,GU, Zhengxiang,HONG, Zhenqiu,O'CONNOR, Stephen
申请号：
ES13795973
公开号：
ES2605856T3
申请日:
2013.11.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, in which: X is independently selected from: a bond, O, S, NH, N (C1 alkyl -4), CH2, CH2CH2, CH (C1-4 alkyl), OCH2, CH2O, OCH2CH2 and CH2CH2O； Ring A is independently ** Formula ** Ring B is independently a 4 to 7-membered saturated heterocycle containing carbon atoms, the nitrogen atom shown in Ring B and 0-1 additional heteroatoms selected from N, O and S； and ring B is substituted with 0-4 R2； R1 is independently CO2R9, SO2R9, ** Formula ** phenyl, benzyl, naphthyl or a 5 to 10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O and S； wherein said phenyl, benzyl, naphthyl and heteroaryl are each substituted with 0-3 R6； R2, at each occurrence, is independently selected from:>； = O, OH, halogen, C1-6 alkyl substituted with 0-1 R12, C1-6 alkoxy substituted with 0-1 R12, C1-4 haloalkyl substituted with 0-1 R12, C1-4 haloalkoxy substituted with 0-1 R12, - (CH2) m-C3-6 carbocycle substituted with 0-1 R12 and - (CH2) m- (5-10 membered heteroaryl containing carbon atoms and 1 -4 heteroatoms selected from N, NR11, O and S)； wherein said heteroaryl is substituted with 0-1 R12； when two R2 groups are attached to two different carbon atoms, they can be combined to form a bridge of carbon atoms of 1 to 3 members over the B ring； when two R2 groups are attached to the same carbon, they can be combined, together with the carbon atom to which they are attached, to form a 3 to 6 member carbon atom containing a spiro ring； R3 is independently selected from: H, halogen, CN, OH, CO2H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, -N (C1-4 alkyl) SO2Ph, OR9, SR9, C (O) OR9, CO2R9, S (O) R9, SO2R9, CONHR9, CON (C1-4 alkyl) 2, - (O) n- (CH2) m- (phenyl substituted with 0-2 R10), - ( O) n- (CH2) m- (5-10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O and S； wherein said heteroaryl
