VU Chi B. (US),ВУ Чи Б. (US),OULMANN Kristofer (US),ОУЛМАНН Кристофер (US),PERNI Robert B. (US),ПЕРНИ Роберт Б. (US),UAJT Brajan (US),УАЙТ Брайан (US),VU CHI B.,ВУ Чи Б.,OULMANN KRISTOFER,ОУЛМАНН Кристофер,PERNI ROBERT B.,ПЕРНИ Роберт Б.,UAJT BRAJAN,УАЙТ Брайан
申请号：
RU2011117160/04
公开号：
RU0002519779C2
申请日:
2009.09.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of structural formula or a salt thereof, where each of Z1, Z2 and Z3 is independently selected from N and C(R9), where not more than one of Z1, Z2 and Z3 is N； each R9 is hydrogen； and is a second chemical bond between either W2 and C(R12), or W1 and C(R12)； W1 is -N=, and W2(R14) is selected from -N(R14)- and -C(R14)=, such that when W1 is -N=, W2(R14) is -N(R14)- and is a second chemical bond between W1 and C(R12)； R11 is selected from phenyl and a heterocycle which is selected from a saturated or aromatic 5-6-member monocyclic ring, which contains one or two or three heteroatoms selected from N, O and S, or an 8-member bicyclic ring which contains one or more heteroatoms selected from N, O and S, where R11 is optionally substituted with one or two substitutes independently selected from halogen, C1-C4 alkyl, =O, -O-R13, -(C1-C4 alkyl)-N(R13)(R13), -N(R13)(R13), where each R13 is independently selected from -C1-C4alkyl； or two R13 together with a nitrogen atom to which they are bonded form a 5-6-member saturated heterocycle, optionally containing an additional heteroatom selected from NH and O, where if R13 is an alkyl, the alkyl is optionally substituted with one or more substitutes selected from -OH, fluorine, and if two R13 together with the nitrogen atom to which they are bonded form a 5-6-member saturated heterocycle, the saturated heterocycle is optionally substituted on any carbon atom with fluorine； R12 is selected from phenyl, a 4-6-member monocyclic saturated ring and a heterocycle, which is selected from an aromatic 5-6-member monocyclic ring which contains one or two heteroatoms selected from N and S, where R12 is optionally substituted with one or more substitutes independently selected from halogen, -C≡N, C1-C4 alkyl, C1-C2 fluorine-substituted alkyl, -O-R13, -S(O)2-R13, -(C1-C4 alkyl)-N(R13)(R13), -N(R13)(R13)； R14 is selected from hydrogen, C1-C4 alkyl, C1-C4 fluorine-substituted alkyl,
