MORTENSEN, DEBORAH SUE,MEDEROS, MARIA MERCEDES DELGADO,SAPIENZA, JOHN JOSEPH,ALBERS, RONALD J.,LEE, BRANDEN G.,HUANG, DEHUA,SCHWARZ, KIMBERLY LYN,PARNES, JASON SIMON,RIGGS, JENNIFER R.,PAPA, PATRICK W
申请号：
ES07861468
公开号：
ES2383370T3
申请日:
2007.10.18
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound having the following formula: and its pharmaceutically acceptable salts, wherein: R 1 is substituted or unsubstituted C 1-8 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl .-XABY- together form -N (R2) CH2C (O) NH-, -N (R2) C (O) CH2NH-, -N (R2) C (O) NH -, - N (R2) CH>； = N-, or -C (R2)>； = CHNH-； L is a direct bond, NH or O； R2 is C1-8 substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl substituted or substituted or unsubstituted heterocycloalkyl； and R3 and R4 are independently H or C1-8 alkyl, where the groups that are substituted are substituted with one or more halogens； C 1-8 alkyl； C 2-8 alkenyl； C2-8 alkynyl； hydroxyl； C1-8 alkoxy； Not me； nitro； thiol； thioether； imine； cyano； amido； phosphonate； phosphine； carboxyl； thiocarbonyl； sulfonyl； sulfonamide； ketone； aldehyde； ester； carbonyl； haloalkyl； B (OH) 2； carbocyclic cycloalkyl, heterocycloalkyl, aryl or monocyclic or fused or polycyclic heteroaryl not fused； amino； O-lower alkyl； O-aryl, aryl； aryl-lower alkyl； CO2CH3； CONH2； OCH2CONH2； NH2； SO2NH2； OCHF2； CF3； or OCF3 groups, where each of these groups is optionally substituted, where aryl denotes an unsaturated aromatic carbocyclic group of 6 to 14 carbon atoms having a single ring or multiple condensed rings； heteroaryl denotes an aryl ring system that has one four heteroatoms selected from O, S and N as ring atoms where the rest of the ring atoms are carbon atoms； cycloalkyl denotes a saturated or unsaturated unsaturated carbocyclic ring； and heterocycloalkyl denotes a non-aromatic cycloalkyl where one to four of the ring carbon atoms are independently replaced with a heteroatom selected from O, S and N； with the proviso that R2 is not a substituted or unsubstituted furanoside and that the compound other than 8,9-
