Compound of formula I: ** Formula ** where R1 is selected from -OH, -CN, -CHO, -COR10, -COOR10, -SO2R10, -CONH2, -CSNH2, - CONR10 ((C (R12) (R13) ) tCO-NR10R11, -CONR10 ((C (R12) (R13)) tCOOR11, -C (>； = S) R10 and -C (>； = NR10) R11； R2 is selected from hydrogen, halogen, -OH, -CN , -CHO, -OCH3, -OCH2CH3, -OCH (CH3) 2, - NO2, -COR10, -COOR10, -SO2R10, -CONR10R11, -CSNR10R11, -CONR10NR11R12, -CONR10OR11, -CONR10 ((C (R12) ( R13)) tCONR10R11, -CONR10 ((C (R12) (R13)) tCOOR11, -C (>； = S) R10, -C (>； = NOR11) R10, - C (>； = NR10) R11, -SO2NR10R11, heterocyclyl , optionally substituted (C1-C6) alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, halo (C1-C6) alkyl, halo (C1-C6) haloalkoxy, and (C1-C6) alkylthio； or, R1 and R2, together with the atoms to which they are attached and a fragment selected from -OCH2O-and -OCH2CH2O-, they form a ring； R3 is selected from hydrogen, hydrocarbon (C1-C8), heterocyclyl, aryl and hydroxyalkyl； R4 is selected from hydrogen , hydr oxyl, amino, (C1-C4) alkoxy, (C1-C20) alkyl and (C1-C20) alkyl substituted with hydroxyl or carbonyl； R5 is (C1-C6) alkyl； R6 is (C1-C6) alkyl； R7 is selected from hydrogen, NR10R11 and -OR10； or R4, R5, R6 and R7 together can form one, two, three or four rings, said rings having an optional additional substitution； R8 and R8a are both hydrogen, or R8 and R8a together are>； = O； R9 is selected from hydrogen and (C1-C6) alkyl； R10, R11, R12 and R13 are, independently in each case, hydrogen, optionally substituted (C1-C6) alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, hydroxy, -NR100R101 or optionally substituted (C1-C4) alkoxy , or R10 and R11, together with the nitrogen atom to which they are attached, form an optionally substituted fused heterocyclic or carbocyclic ring, of 5 to 7 ring members, of which up to 3 can be heteroatoms selected from N, O and S ； t is 0, 1, 2, 3, 4, 5 or 6；Compuesto de
