Abstract A compound separated from Monascus-fermented rice, thepreparation method and uses thereofThe present invention discloses a compound separated from Monascus-fermented rice, the preparation method and uses thereof. Specifically, the present invention discloses a compound represented by the Formula I, or a pharmaceutically acceptable salt thereof, wherein, R1 is selected from the group consisting of hydrogen, hydroxyl, C1_6 straight or branched alkoxyl, (II), (Ill) and (IV); R2 is hydrogen or C1_6 alkyl; R3 is selected from the group consisting of hydrogen, hydroxyl and C1-6 straight or branched alkoxyl. The present invention further discloses a pharmaceutical composition containing the compound. The compound of the present invention has HMG-CoA reductase inhibition effects. CH3 CH3 CH3(IV)