BROWN, GILES,HIGGINBOTTOM, MICHAEL,STEWART, ALISON,PATIENT, LEE,CARLEY, ALLISON,SIMPSON, IAIN,SAVORY, EDWARD DANIEL,OLIVER, KATHRYN,COLE, ANDREW GRAHAM
申请号：
ES11773227
公开号：
ES2536281T3
申请日:
2011.10.13
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** wherein: R1 is selected from C1-4 alkyl, cyano, -COR3, -CONR3R4 and heteroaryl, wherein (a) said heteroaryl is optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-6 alkyl, C3-5 cycloalkyl, C1-4 alkoxy, C1-6 fluoroalkyl, C1-4 fluoroalkoxy, (C1-4) alkoxy - (C1-4) alkyl, (C1-4) fluoroalkoxy-(C1-4) alkyl, C6-10 aryl, heteroaryl, -NR5AR5B, -NC (C1-4) -NR5AR5B, -NR4C (O) O-alkyl ( C1-4), -NR4C (O) -alkyl (C1-4), -NR4C (O) O-fluoroalkyl (C1-4), -NR4C (O) -fluoroalkyl (C1-4), -NR4C (O) NR5AR5B, -C (O) NR5AR5B, -C (O) R4, -C (O) OR4, -NR4S (O) 2-alkyl (C1-4) and -NR4S (O) 2-fluoroalkyl (C1-4) , and (b) said C1-4 alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4 alkoxy； X is selected from radicals of formulas (A) - (F) inclusive, any of which is optionally substituted with one or more substituents independently selected from halogen, cyano, nitro, C1-4 alkyl, C1-4 alkoxy, C1- fluoroalkyl 4 and C1-4 fluoroalkoxy, wherein the labeled link * is attached to R1 and the labeled link ** is attached to Y: ** Formula ** Y is selected from radicals of formulas (H), (J), (K ) and (M), any of which is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4 alkyl, a divalent C1-4 alkylene radical that forms a bridge between carbons of the ring of said homopiperazine or piperazine , C1-4 alkoxy, C1-4 fluoroalkyl, a divalent C1-4 fluoroalkylene radical that forms a bridge between the ring carbons of said homopiperazine or piperazine and C1-4 fluoroalkoxy, wherein the labeled bond * is attached to X and the bond marked ** is attached to R2: ** Formula ** ynym are c Ada one independently 1 or 2； R2 is selected from radicals of formulas (N) - (R) inclusive, any of which is optionally substituted with one or more substituents inde
