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Moduladores del receptor NMDA y sus usos
专利权人:
Northwestern University
发明人:
KHAN, Amin,MOSKAL, Joseph,WOOD, Paul
申请号:
ES09815233
公开号:
ES2553968T3
申请日:
2009.09.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the formula: ** ** Formula and their salts, stereoisomers and N-oxides, pharmaceutically acceptable in which i) to a compound represented by formula I: T is independently at each occurrence, CR4R4 , n is 0, 1, 2 or 3 A is optionally present and is selected from phenyl or pyridine, wherein A is optionally substituted with one or more substituents selected from Ra R1 is selected from the group consisting of H, hydroxyl, -S (O) 2-C1-C4alkyl, C1-C4alkyl, C2-C4alquenilo, phenyl, R7, or Formula ** ** where C1-C4alkyl, C2-C4alquenilo, or phenyl optionally substituted with one or more substituents selected from Ra X is CH or N R3 and R3 are independently selected from the group consisting of H, halogen, hydroxyl, phenyl, C1-C4alkyl, amido, amine, or C2-C4alquenilo where C1-C4alkyl, C2-C4alquenilo and phenyl chosen are optionally substituted with one or more substituents selected from Ra R4 and R4 are independently from the group consisting of H, halogen, hydroxyl, phenyl, C1-C4alkyl, amido, amine, C1-C4alkoxy or C2-C4alquenilo where C1-C4alkyl, C2-C4alquenilo C1-C4alkoxy and phenyl choose are optionally substituted with one or more substituents selected from Ra R2 is selected from the group consisting of H, R7, S (O) 2-C1-C4alkyl, C1-C4alkyl, hydroxyl or C1- C4alkyl and phenyl where phenyl is optionally substituted with one or more substituents selected from Ra R5 and R5 are selected, each independently, from the group consisting of H, halogen, C1-C4alkyl, C1- C4alkoxy, C2-C4alquenilo, cyano, amino, phenyl and hydroxyl, wherein C1-C4alkyl, C2-C4alquenilo and phenyl they are optionally substituted with one or more substituents selected from Ra R7 is selected from the group consisting of -C (O) -C1-C4alkyl or C (O) -O-C1-C4alkyl, C1-C4alkyl which is optionally substituted with 1, 2 or 3 substituents selected from Rb R8 is selected from the group consisting of H, -C (O) -C1-C4alkyl or C (O) -O- C1-C4alkyl, C1-C4alkyl which is optionally substituted wi
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