CONJUGUES D'ACIDE PHENYLETHANOIQUE, D'ACIDE PHENYLPROPANOIQUE ET D'ACIDE PHENYLPROPENOIQUE ET PROMEDICAMENTS D'HYDROCODONE, LEURS PROCEDES DE FABRICATION ET D'UTILISATION
MICKLE, TRAVIS,GUENTHER, SVEN,MICKLE, CHRISTAL,CHI, GUOCHEN,KANSKI, JAROSLAW,MARTIN, ANDREA K.,BERA, BINDU
申请号：
CA2765836
公开号：
CA2765836C
申请日:
2010.07.01
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
