Christal Mickle;Guochen Chi;Travis Mickle;Jaroslaw Kanski;Sven Guenther;Bindu Bera;Andrea K. Martin
发明人:
Travis Mickle,Sven Guenther,Christal Mickle,Guochen Chi,Jaroslaw Kanski,Andrea K. Martin,Bindu Bera
申请号：
US12828456
公开号：
US08871780B2
申请日:
2010.07.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
