GUOCHEN CHI;TRAVIS MICKLE;KEMPHARM INC.;JAROSLAW KANSKI;ANDREA K.MARTIN;SVEN GUENTHER;BINDU BERA
发明人:
申请号：
IL23182214
公开号：
IL231822D0
申请日:
2014.03.31
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-&alpha；-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
