The method that bright one Seed of Department Off whats of this Hair inhibit Tyrosine ferment element Turn Translation, it includes the Turn Translation inhibited in Fine born of the same parents by the 2nd sequence column District TIF-2 institutes Knitting Code segments of the first sequence column District TIF-1 of Tyrosine ferment or Tyrosine ferment. This Hair Ming Yi Off Yu mono- Seed inhibit Wheat to draw the method for Ning melanin (melanin) generation, can inhibit the nucleic acid molecules of Tyrosine Jiao Su Turn Translation or Wheat drawing Ning melanin productions Ji Medical Drug Group close object.本發明係關於一種抑制酪胺酸酵素轉譯之方法,其包含抑制細胞中由酪胺酸酵素第一序列區TIF-1或酪胺酸酵素第二序列區TIF-2所編碼片段之轉譯。本發明亦關於一種抑制麥拉寧黑色素(melanin)生成之方法、可抑制酪胺酸酵素轉譯或麥拉寧黑色素生成之核酸分子及醫藥組合物。