3-[(3-{[4-(4-嗎啉基甲基)-1H-吡咯-2-基]亞甲基}-2-側氧基-2,3-二氫-1H-吲哚-5-基)甲基]-1,3-噻唑啶-2,4-二酮及EGFR TYR激酶抑制劑之新穎結合物农业专利-农业学术服务平台

发明人:: BURBRIDGE, MICHAEL,伯布利基　麦克,伯布利基　麥克,CATTAN, VALERIE,卡坦　薇乐利,卡坦　薇樂利,JACQUET-BESCOND, ANNE,杰科特　贝司康得　安,傑科特　貝司康得　安,伯布利基麦克,伯布利基麥克,卡坦薇乐利,卡坦薇樂利,杰科特贝司康得安,傑科特貝司康得安

摘要：: Association between 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione of formula (I): or a Z or E isomer thereof and/or an addition salt thereof with a pharmaceutically acceptable acid or base, and a human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.本發明係關於式(I)之3-[(3-{[4-(4-嗎啉基甲基)-1H-吡咯-2-基]亞甲基}-2-側氧基-2,3-二氫-1H-吲哚-5-基)甲基]-1,3-噻唑啶-2,4-二酮：或其Z或E異構物及/或其與醫藥上可接受之酸或鹼之加成鹽，與人類表皮生長因子受體(EGFR)酪胺酸激酶抑制劑之結合物。本發明係關於一種藥劑。