MINHUA CHEN,YANFENG ZHANG,CHAOHUI YANG,XIAOYU ZHANG,PENG WANG,JIAOYANG LI,PIXU LI
申请号：
PT15843405
公开号：
PT3229799T
申请日:
2015.12.08
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
Novel crystalline Form I of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2'- (pentanoyl {2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl}amino)butyrate] hydrate, methods for its preparation, pharmaceutical compositions comprising the new form, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.
