FORMES CRISTALLINES DE COMPLEXE SUPRAMOLECULAIRE DE TRISODIUM COMPRENANT DU VALSARTAN ET AHU-377 AINSI QUE PROCEDES ASSOCIES

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专利权人:

CRYSTAL PHARMATECH CO., LTD.;SUZHOU PENGXU PHARMATECH CO., LTD.

发明人:

CHEN, MINHUA,ZHANG, YANFENG,YANG, CHAOHUI,ZHANG, XIAOYU,LI, JIAOYANG,WANG, PENG,LI, PIXU

申请号：

CA2970192

公开号：

CA2970192A1

申请日:

2015.12.08

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Novel crystalline Forms of trisodium [3-((1S,3R)-l-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl{2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.

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