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Composite oncolytic herpes virus vectors
专利权人:
Niza Frenkel
发明人:
Niza Frenkel
申请号:
US10476451
公开号:
US08216564B2
申请日:
2002.05.02
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Pharmaceutical compositions including a herpes simplex virus derived composite oncolytic vector are provided for the treatment of solid tumors in an individual. The HSV-derived composite oncolytic vector includes an HSV-derived amplicon defective viral genome carrying at least one toxic foreign gene, and an HSV-derived mutant helper virus vector that has a mutation in the vhs-1 gene. An HSV-derived mutant helper virus vector that has a mutation in the vhs-1 gene is also provided. A method for the treatment of an individual having a solid tumor is provided and includes administering an HSV-derived amplicon defective viral genome including at least one toxic foreign gene, and an HSV-derived mutant helper virus vector including a mutation in the vhs-1 gene.
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