Justus B. Cohen; III;Joseph C. Glorioso;Joseph C. Glorioso, III;Hiroaki Uchida
发明人:
Joseph C. Glorioso, III,Hiroaki Uchida,Justus B. Cohen
申请号：
US13641649
公开号：
US09593347B2
申请日:
2011.04.18
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV vectors of the present invention can directly infect cells through interaction with cell proteins other than typical mediators of HSV infection. In another aspect, the invention provides an HSV vector, which exhibits lateral spread in cells typically resistant to HSV lateral spread, such as cells lacking gD receptors. The invention further provides DNA encoding mutant forms of the HSV gB and gH glycoproteins, stocks of the inventive virus, and methods for effecting viral targeting and efficient entry of cells. The invention also pertains to the use of the inventive vectors for treating cancers.
