University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Joseph C. Glorioso, III,Hiroaki Uchida,Justus B. Cohen
申请号：
US16417254
公开号：
US20200147189A1
申请日:
2019.05.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type； and (b) a mutant envelope glycoprotein other than gD.
