HUANG, KE MING,黄可名,黃可名,CHEN, HE RU,陈和儒,陳和儒,HONG, KEELUNG,洪 基隆,洪 基隆
申请号：
TW106126551
公开号：
TW201806585A
申请日:
2017.08.07
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
Provided is a method for preparing a liposomal composition. The method comprises the step of contacting a liposome solution with a mild acidic agent for a limited time. The liposome solution comprises a weak acid salt encapsulated within an aqueous interior space separated from the aqueous medium by a membrane comprised of a lipid mixture containing one or more lipids and a hydrophilic polymer conjugated lipid at a molar percentage of less than 3% based on the total amount of the lipid mixture. The time for encapsulating the agent to a desired amount at a predetermined ratio to lipids is dramatically reduced even under a condition without elevating the temperature to above ambient environment.提供一種製備微脂體組合物的方法。該方法包含使一微脂體溶液與一弱酸性劑在有限的時間內接觸的步驟。該微脂體溶液包含一弱酸式鹽，該弱酸式鹽被包覆在一水性內部空間內。該水性內部空間係由含有一種或多種脂質及一親水性聚合物共軛脂質的脂質混合物所組成之膜與水性介質分隔，基於該脂質混合物的總量，該親水性聚合物共軛脂質的莫耳百分比小於3%。即使在不將溫度升高到高於周圍環境的條件下，將該藥劑包覆到所需量的與脂質預定比例的時間也會顯著減少。
