Described herein is a stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of natalizumab (optionally not subjected to prior lyophilization), a buffer effective to maintain the pH in the range from about 4.0 to about 7.0； and optionally, one or more surfactant(s), one or more amino acid(s), one or more sugar(s), one or more polyol(s), one or more chelating agent(s), one or more polymer(s), one or more other stabilizing agent (s)； and methods for making such a formulation； and methods of using such a formulation.本文揭露一種穩定水性藥學調配物，其包含治療有效量之那他珠單抗(可選擇地不進行預先冷凍乾燥)、有效維持pH值在約4.0至約7.0之範圍的緩衝劑；以及可選擇地，一或多個界面活性劑、一或多個胺基酸、一或多個糖類、一或多個聚醇、一或多個螫合劑、一或多個聚合物、一或多個穩定劑。本文還揭露一種製作此調配物的方法，以及一種使用此調配物的方法。
