Max Planck Institute of Colloids and Interfaces;Jiangnan University
发明人:
Jian YIN,Jing HU,Peter Seeberger,Chunjun QIN
申请号：
US16215349
公开号：
US20190233459A1
申请日:
2018.12.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides, and the like.
