MASSACHUSETTS INSTITUTE OF TECHNOLOGY;TRUSTEES OF BOSTON UNIVERSITY
发明人:
James J. Collins,Timothy Kuan-Ta Lu
申请号：
US13953114
公开号：
US20140161772A1
申请日:
2013.07.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin B (DspB), an enzyme that hydrolyzes β-1,6-N-acetyl-D-glucosamine, a crucial adhesion molecule needed for biofilm formation and integrity in Staphylococcus and E. coli, including E. coli K-12, as well as clinical isolates.
