Compound of formula (I): in which: n1 and R2 are each independently a monocyclic, bicyclic or polycyclic, aromatic or partially aromatic 5-12 membered ring system in which each ring system independently comprises 0-3 heteroatoms selected from the group consisting of N, 0, S, S (0) and S (0) 2, and each ring system is substituted with 0-5 substituents independently selected from Y； in which Y comprises halo, hydroxy, cyano, thio, nitro, trifluoromethyl, oxo, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, alkoxy, methylenedioxy, ethylenedioxy, NH (R) , N (R) 2, SR, C (0) NH (R), C (0) N (R) 2, RC (0) N (R), C (0) C (0) NR2, C (0 ) C (0) 0R, RC (0) 0, ROC (0), ROC (0) 0, RC (0), RS02, RS02-alkyl (C1-C3), SO2N (R) 2, N (R) S02R, urea carrying 0-3 R, aryl (C3-C10), heteroaryl (C2-C10), dihydroheteroaryl (C2-C10), tetrahydroheteroaryl (C2-C10), hexahydroheteroaryl (C2-C10), mono or bicyclic cycloalkyl ( C3-C10), or mono- or bicyclo-heterocyclyl (C2-C10), in which each R independently comprises hydrogen or substituted or unsubstituted aryl or substituted or unsubstituted (C1-C6) alkyl, or in which two groups R taken together with a nitrogen atom to which they are attached together with the nitrogen atom form a heterocyclic ring comprising 0-2 additional heteroatoms selected from the group consisting of N, 0, S, S (0) and S (0) 2, and substituted with 0-3 alkyl groups (C1-C3), hydroxyl, hydroxyalkyl (Ci-C3) or (C-C3) alkoxy (ci-c3) alkyl； in which any alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, dihydroheteroaryl, tetrahydroheteroaryl, hexahydroheteroaryl, cycloalkyl or heterocyclyl of Y or R, or both, may be further substituted with 1-3 substituents selected from halo, hydroxyl, cyano, thio, nitro, trifluoromethyl, oxo, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, alkoxy, methylenedioxy, ethylenedioxy, NH (R), N (R) 2, SR, C ( 0) NH (R), C (0) N (R) 2, RC (0) N (R), C (0) C (0) NR2, C (0) C (0) 0R, RC (0) 0, ROC (0), ROC (0) 0, RC (0), RS02, RS02-alkyl (C1-C3),
