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Imidazopiridinas and imidazopirazinas as LSD1 inhibitors
专利权人:
INCYTE CORPORATION
发明人:
ZHIYONG YU,NEIL LAJKIEWICZ,LEAH KONKOL,COLIN ZHANG,WENQUING YAO,MEIZHONG XU,LIANG LU,LIANGXING WU
申请号:
ARP150102198
公开号:
AR101175A1
申请日:
2015.07.10
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
1. This list relates to pyridine [1,5-a] pyridine and pyridine [1,5-a] pyridine derivatives, which are LSD1 inhibitors used in the treatment of cancer and other diseases. 1. Claim 1: a formula compound (1),or one of its pharmaceutically acceptable salts, characterized in that: X is N or CRX; ring A is C₆₋₁₀ aryl or 5-10 membered heteroaryl comprising carbon and 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein said C₆₋₁₀ aryl and 5-10 membered heteroaryl they are optionally substituted with 1, 2, 3, or 4 substituents independently selected from RA; ring B is aryl C₆₋₁₀;a. A heteromorphism consisting of 5-10 members, including carbon and 1, 2, 3 or 4 heteromorphic atoms selected from n, O, y, s;or 4-10 membered heterocycloalkyl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; where said aryl C₆₋₁₀,5-10 membered heteroaryl, C₃₋₁₀ cycloalkyl,and 4-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 substituents independently selected from RB; R¹ is halo, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;C₁₋₆ haloalkyl,Cy1,CN ORSRᵃ¹,C (O) RC (O) NR RC (O) OROC (O) ROC (O) NR RNR RNo. 7580;; 1 C (o) r7495;; 1No. 7580; 1 C (o) or7491; 1,NR C (O) NR RC (3DNR) RC (3DNR) NR RNR C (3DNR) NR RNR S (O) RNR S (O) RNR S (O) NR RS (O) RS (O) NR RS (O) Ry S (O) NR Rwhere said C₁₋₆ alkyl,C₂₋₆ alkenyl,and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy¹,halo CN ORSRᵃ¹,C (O) RC (O) NR RC (O) OROC (O) ROC (O) NR RNR RNo. 7580;; 1 C (o) r7495;; 1No. 7580; 1 C (o) or7491; 1,NR C (O) NR RC (3DNR) RC (3DNR) NR RNR C (3DNR) NR RNR S (O) RNR S (O) RNR S (O) NR RS (O) RS (O) NR RS (o) 8322;; r74955;; 1 and S (o) 8322;; nr7580808;; 1 r7496;; 1R³ is H, halo, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;C₁₋₆ haloalkyl,ScionCN ORSRᵃ³,C (O) RC (O) NRᶜ³Rᵈ³,C (O) OROC (O) ROC (O) NR RNR RNR C (O) RNo. 7580; 3 C (o) or7491; 3,No. 7580; + C (o) 7580; + r749696; + 3C (= No. 749773; 3) r74955; 3C
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