您的位置: 首页 > 农业专利 > 详情页

As imidazopirazinas LSD1 inhibitors
专利权人:
INCYTE CORPORATION
发明人:
YAPING SUN,JINGWEI LI,JOEL R. COURTER,JINCONG ZHUO,COLIN ZHANG,WENQUING YAO,XIAOZHAO WANG,LIANG LU,CHUNHONG HE,LIANGXING WU
申请号:
ARP150102197
公开号:
AR101174A1
申请日:
2015.07.10
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
1. This list is aimed at [1,2-a] pyrethroid derivatives, which are LSD1 inhibitors used to treat cancer and other diseases. 1. Claim 1: a formula compound (1),or one of its pharmaceutically acceptable salts, characterized in that: ring A is C₆₋₁₀ aryl or 5-10 membered heteroaryl comprising carbon and 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein said C₆₋₁₀ aryl and 5-10 membered heteroaryl are optionally substituted with 1, 2, 3, or 4 substituents independently selected from RA; ring B is aryl C₆₋₁₀;a. A heteromorphism consisting of 5-10 members, including carbon and 1, 2, 3 or 4 heteromorphic atoms selected from n, O, y, s;or 4-10 membered heterocycloalkyl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; where said aryl C₆₋₁₀,5-10 membered heteroaryl, C₃₋₁₀ cycloalkyl,and 4-10 membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 substituents independently selected from RB; R¹ is halo, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;C₁₋₆ haloalkyl,Cy1,CN ORSRᵃ¹,C (O) RC (O) NR RC (O) OROC (O) ROC (O) NR RNR RNo. 7580;; 1 C (o) r7495;; 1No. 7580; 1 C (o) or7491; 1,NR C (O) NR RC (3DNR) RC (3DNR) NR RNR C (3DNR) NR RNR S (O) RNR S (O) RNR S (O) NR RS (O) RS (O) NR RS (O) Ro S (O) NR Rwhere said C₁₋₆ alkyl,C₂₋₆ alkenyl,and C₂₋₆ alkynyl are optionally substituted with 1, 2, or 3 substituents independently selected from Cy¹,halo CN OH ORSRᵃ¹,C (O) RC (O) NR RC (O) OROC (O) ROC (O) NR RNR RNo. 7580;; 1 C (o) r7495;; 1No. 7580; 1 C (o) or7491; 1,NR C (O) NR RC (3DNR) RC (3DNR) NR RNR C (3DNR) NR RNR S (O) RNR S (O) RNR S (O) NR RS (O) RS (O) NR RS (O) Ry S (O) NR RR² and R³ are independently selected from H, halo, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;C₁₋₆ haloalkyl,ScionCN OR7491;C (O) RC (o) No. 758080; R 7496;]C (O) OROC (O) ROC (O) NR R7580; 749696;No. 7580; - No. 7495;No. 7580; C (o) 7491; 22. No. 7580; 2 C (o) No. 7580; 2C (3DNR) RC (3DNR) NR RNR C (3DNR) NR RNo. 7580; No. 7495;Nr7580802 km2 (o) 83222;
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充