ANDREW P. COMBS,THOMAS P. MADUSKUIE,NIKKO FALAHATPISHEH
申请号：
ARP150101214
公开号：
AR100160A1
申请日:
2015.04.22
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
At present, they are related to substituted pyridine and substituted pyridine. They constitute B protein inhibitors such as BRD2, Bd3, bd4 and brd-t, which are helpful for the treatment of cancer and other diseases. 1. Claim 1: a formula compound (1),O select a medically acceptable salt from this product with the following characteristics: x = C = or cr831222； r8313；This is O, s, or nr.83044；Z is CH or N； each of R¹ and R² are independently selected from H, halo, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl,Cy1,CN ORSRᵃ¹,C (O) RC (O) NR RC (O) OROC (O) ROC (O) NR RNR RNo. 7580；； 1 C (o) r7495；； 1No. 7580； 1 C (o) or7491； 1,NR C (O) NR RC (3DNR) RC (3DNR) NR RNR C (3DNR) NR RNR S (O) RNR S (O) RNR S (O) NR RS (O) RS (O) NR RS (O) Ry S (O) NR Rwhere each of said C₁₋₆ alkyl,C₂₋₆ alkenyl,and C₂₋₆ alkynyl are optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from RA； or R¹ and R² together with the carbon atom to which they are attached form a C₃₋₁₀ cycloalkyl group or a 4-10 membered heterocycloalkyl group, each optionally substituted with 1, 2 or 3 substituents independently selected from RA； R³ is H or C₁₋₆ alkyl optionally substituted with 1, 2 or 3 substituents independently selected from halo, Cy, CN, NO₂,Or7491.,7491；C (O) RC (o) No. 758080； R 7496；]C (O) OROC (O) ROC (O) NR RC (3DNR) NR RNR C (3DNR) NR R7580； 749696；No. 7580； - No. 7495；No. 7580； C (o) 7491； 22. No. 7580； 2 C (o) No. 7580； 2No. 7580； No. 7495；Nr7580802 km2 (o) 83222； r74955 km2,NR S (O) NR RS (O) RS (o) No. 7580； R 7496；]S (o) 8322； r74952 and S (o) 8322； nr7580； r74962；R es H halo alquilo CC₂₋₄ alkenyl,1. C 83228331 asphalt；C₁₋₄ haloalkyl,CN ORSRᵃ³,C (O) RC (O) NRᶜ³Rᵈ³,C (O) OROC (O) ROC (O) NR RNR RNR C (O) RNo. 7580； 3 C (o) or7491； 3,No. 7580； + C (o) 7580； + r749696； + 3C (= No. 749773； 3) r74955； 3C (= No. 749773； 3) No. 7580； 3 r749696； 3NR C (3DNR) NR RNR S (O) RNR S (O) RNR S (O) NR RS (O) RS (o) No. 7580； 3 r749696； 3S (O) Ro S (O) NR RR es
