SARGENT BRUCE JEREMY,PAULS HENRY,BERMAN JUDD M.,RAMNAUTH JAILALL,SAMPSON PETER,TORO ANDRAS,MARTIN FERNANDO J. L.,SURMAN MATTHEW DAVID,DECORNEZ HELENE YVONNE,MANNING DAVID DOUGLAS,SARGENT Bruce Jeremy,PAULS Henry,BERMAN Judd M.,RAMNAUTH Jailall,SAMPSON Peter,TORO Andras,MARTIN FERNANDO J.
申请号：
SI200531900
公开号：
SI1828167T1
申请日:
2005.06.06
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The present application relates to antibacterial compounds (Fab1 inhibitors) of formula (I) wherein, independently for each occurrence, A is a monocyclic ring of 4-7 atoms containing 0-2 heteroatoms, a bicyclic ring of 8-12 atoms containing 0-4 heteroatoms, or a tricyclic ring of 8-12 atoms containing 0-6 heteroatoms, wherein the rings are independently aliphatic, aromatic, heteroaryl or heterocyclic in nature, the heteroatoms are selected from N, S, or O, and the rings are optionally substituted with one or more substituents selected from the group consisting of C 1-4 alkyl, OR", CN, OCF 3 , F, Cl, Br, and I； wherein R" is H, alkyl, aralkyl, or heteroaralkyl； R is wherein, independently for each occurrence, R 4 is H, alkyl, aryl, hydroxy substituted alkyl, or -C(O)ONa； R 5 is H, alkyl, or aryl； R 6 is H, alkyl, or aryl； and L 1 is O or H 2 ； or a pharmaceutically acceptable salt thereof.
