The present invention relates a pharmaceutical composition comprising quinoline derivatives or salt thereof. In particular, the present invention relates a pharmaceutical composition comprising (R,E)-N-(4-(3-chloro-4-(pyridyl-2-methoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)-acrylamide or its pharmacologically acceptable salts, crospolyvinylpyrrolidone and at least one pharmacologically acceptable excipient. The composition has the characteristics of rapid dissolution.本發明提供了一種含有喹啉衍生物或其鹽的藥物組成物。具體而言，本發明提供了一種藥物組成物，含有(R,E)-N-(4-(3-氯-4-(吡啶-2-基甲氧基)苯基胺基)-3-氰基-7-乙氧基喹啉-6-基)-3-(1-甲基吡咯烷基-2-基)-丙烯醯胺或其藥理學上可接受的鹽、交聯聚乙烯吡咯烷酮以及至少一種藥學上可接受的賦形劑。本發明的藥物組成物具有溶出迅速的特點。
