Refers to compounds derived from 3 - (hetero aryl alkyl) amino) - 8 - 2 - oxo - 1.3 - Grabarsky, ITs The Wrong Guy spiro [4.5] - Dean of formula (i) wherein n is 1 to 3 R1 and R2 are each - H c1-c6 alkyl, optionally substituted cycloalkyl, optionally substituted C3 - C12 alkyl, among others R3 is C1 - C6C3 - C12 cycloalkyl, among others R4 is H, alkyl of C1 - C6, among others R5 is aryl or heteroaryl C6 to C14 5 14 members R7, R8, R11, R12, R13, R14, R15 and R16, R17 and R18, R19, R20 each HF -, CL -, BR -, I - Oh, among others. Preferred compounds are: cis - 1 - (cyclobutyl methyl) - 8 - - [3 - (dimethylamino) - 4 - phenyl) methyl] - 4 - phenyl - 1.3 - diazaespiro [4.5] decan 2 - One cis - 1 - (cyclobutyl methyl) - 8 - dimethylamino - [3 - (3-methoxyphenyl) methyl] - 4 - phenyl - 1.3 - diazaespiro [4.5] decan 2 - One among others. It also relates to a Pharmaceutical composition.These compounds are useful as opioid receptor modulators in the treatment of PainSE REFIERE A COMPUESTOS DERIVADOS DE 3-((HETERO)ARIL)-ALQUIL-8-AMINO-2-OXO-1,3-DIAZA-ESPIRO-[4.5]-DECANO DE FORMULA (I) DONDE n ES DE 1 A 3 R1 Y R2 SON CADA UNO -H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO, CICLOALQUILO C3-C12 OPCIONALMENTE SUSTITUIDO, ENTRE OTROS R3 ES ALQUILO C1-C6, CICLOALQUILO C3-C12, ENTRE OTROS R4 ES H, ALQUILO C1-C6, ENTRE OTROS R5 ES ARILO C6-C14 O HETEROARILO DE 5 A 14 MIEMBROS R7, R8, R11, R12, R13, R14, R15, R16, R17, R18, R19 Y R20 SON CADA UNO -H, -F, -Cl, -Br, -I, -OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: CIS-1-(CICLOBUTIL-METIL)-8-DIMETILAMINO-3-[(4-METILSULFONIL-FENIL)-METIL]-8-FENIL-1,3-DIAZAESPIRO[4.5]DECAN-2-ONA CIS-1-(CICLOBUTIL-METIL)-8-DIMETILAMINO-3-[(3-METOXIFENIL)-METIL]-8-FENIL-1,3-DIAZAESPIRO[4.5]DECAN-2-ONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE RECEPTORES OPIOIDES SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR
