您的位置: 首页 > 农业专利 > 详情页

Heterocycles as inhibitors of FGFR bicicliclos
专利权人:
INCYTE HOLDINGS CORPORATION
发明人:
HE, CHUNHONG,LU, LIANG,QIAN, DING-QUAN,SUN, YAPING,ZHUO, JINCONG,XU, MEIZHONG,YAO, WENQING,ZHANG, FENGLEI,WU, LIANGXING
申请号:
PE0022362015
公开号:
PE20332015A1
申请日:
2014.04.18
申请国别(地区):
PE
年份:
2016
代理人:
摘要:
The present Invention relates to bicyclic Heterocycles of General formula (i), and Pharmaceutical compositions thereof, which are inhibitors of one or more Enzymes of FGFR and are useful in the treatment of related diseases such as cancer, FGFR, where W is R0 R1 is alkyl, etc. C1 - C6, etc. R2, R3 and R5 are h, Halo, Halo is H etc. R4, R6 H Halo, etc., etc.R7 and R8 is H, alkyl etc.r9 C1 - C6 C1 - 6 IS h, alkyl, etc.. The preferred compounds are among others: 7-amino-3 - (2,6 - difluoro - 3.5 - dimetoxifenil) - 1.8 - dimethyl - 3.4 - dihidropirido [4,3-d] - 2 (1H) - pyrimidine ona; 7-amino-3 - (2,6 - Difluoro - 3.5 - dimetoxifenil) - 8 - 1 - methyl - ethyl - 4 - dihidropirido [4, 3 - d] pyrimidine - 2 (1H) - OneLa presente invencion se refiere a heterociclos biciclicos de formula (I), y composiciones farmaceuticas de estos, que son inhibidores de una o mas enzimas del FGFR y son utiles en el tratamiento de enfermedades relacionadas con el FGFR, como el cancer, donde: W es R9, etc. R1 es alquilo C1-C6, etc. R2, R3 y R5 son H, halo, etc. R4 es H, halo, etc. R6 es H, halo, etc. R7 y R8 son H, alquilo C1-C6, etc.R9 es H, alquilo C1-6,etc. los compuestos preferidos son entre otros:7-amino-3- (2,6-difluoro-3,5-dimetoxifenil)-1,8-dimetil-3,4-dihidropirido [4,3-d]pirimidin-2 (1H)-ona;7-amino-3-(2,6- difluoro-3,5-dimetoxifenil)-8-etil-1-metil-3,4-dihidropirido[4,.3-d] pirimidin-2 (1H)-ona
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充