It refers to the compound produced from 3 - ((ISO) aril) - alkyl-8-amino-2-oxo-1, 3-diazo-helix - [4.5] - formula substitute (I), n is 1-3； R1 and R2 are each kind of - H, C1-C6 alternative asphalt, c3-c12 alternative asphalt, among others； R3 is C1-C6, c3-c12 short chain chlorinated paraffin, others； C14 is C16, short chain chlorinated paraffin, short chain chlorinated paraffin. Others； R5 is arilo C6-C14 or 5-14 heterogeneous； R7, R8, R11, R12, R13, R14, R15, R16, R17, R18, R19 and R20 are h, F, Cl, Br, I, oh, etc., respectively. The most popular compounds are cis-1 - (cyclo methyl) - 8-dimethylamine-3 - [(4-methylene sulfur-phenyl) - methyl] - 8-phenyl-1,3-diazo [4.5] decan-2-ona；Cis-1 - (cyclomethyl) - 8-dimethylamine-3 - [(3-methoxyphenyl) - methyl] - 8-phenyl-1, 3-diazo [4.5] decan-2-ona； He also mentioned a pharmaceutical composer These compounds are opioid receptor modulators for pain treatmentSE REFIERE A COMPUESTOS DERIVADOS DE 3-((HETERO)ARIL)-ALQUIL-8-AMINO-2-OXO-1,3-DIAZA-ESPIRO-[4.5]-DECANO DE FORMULA (I) DONDE n ES DE 1 A 3； R1 Y R2 SON CADA UNO -H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO, CICLOALQUILO C3-C12 OPCIONALMENTE SUSTITUIDO, ENTRE OTROS； R3 ES ALQUILO C1-C6, CICLOALQUILO C3-C12, ENTRE OTROS； R4 ES H, ALQUILO C1-C6, ENTRE OTROS； R5 ES ARILO C6-C14 O HETEROARILO DE 5 A 14 MIEMBROS； R7, R8, R11, R12, R13, R14, R15, R16, R17, R18, R19 Y R20 SON CADA UNO -H, -F, -Cl, -Br, -I, -OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: CIS-1-(CICLOBUTIL-METIL)-8-DIMETILAMINO-3-[(4-METILSULFONIL-FENIL)-METIL]-8-FENIL-1,3-DIAZAESPIRO[4.5]DECAN-2-ONA； CIS-1-(CICLOBUTIL-METIL)-8-DIMETILAMINO-3-[(3-METOXIFENIL)-METIL]-8-FENIL-1,3-DIAZAESPIRO[4.5]DECAN-2-ONA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE RECEPTORES OPIOIDES SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR
