ANDREI V. BLOKHIN,DARREN H. WAKEFIELD,DAVID B. ROZEMA,DAVID L. LEWIS,ERIC KITAS,GUENTHER OTT,HANS MARTIN MUELLER,INGO ROEHL,JEFFREY C. CARLSON,JON A. WOLFF,JONATHAN D. BENSON,KERSTIN JAHN-HOFMANN,PETE
申请号：
BR112013011702
公开号：
BR112013011702A2
申请日:
2011.12.16
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
