Rozema, David B.,Lewis, David L.,Wakefield, Darren H.,Kitas, Eric,Hadwiger, Philipp,Wolff, Jon A.,Roehl, Ingo,Mohr, Peter,Hoffman, Torsten,Jahn-Hofmann, Kerstin,Mueller, Hans Martin,Ott, Guenther,Blok
申请号：
AU2015210397
公开号：
AU2015210397A1
申请日:
2015.08.06
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015210397A120150903.pdf#####Abstract The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
