HADWIGER, PHILIPP,HOFFMANN, TORSTEN,KITAS, ERIC A.,LEWIS, DAVID L.,MOHR, PETER,ROZEMA, DAVID B.,THUER, WILMA,VALIS, LINDA CHRISTINE,WAKEFIELD, DARREN H.
申请号：
CA2788600
公开号：
CA2788600C
申请日:
2011.02.18
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
