HADWIGER, PHILIPP,HOFFMANN, TORSTEN,KITAS, ERIC A.,LEWIS, DAVID L.,MOHR, PETER,ROZEMA, DAVID B.,THUER, WILMA,VALIS, LINDA CHRISTINE,WAKEFIELD, DARREN H.
申请号：
PL11703711
公开号：
PL2539451T3
申请日:
2011.02.18
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
