HADWIGER PHILIPP,HOFFMANN TORSTEN,KITAS ERIC A,LEWIS DAVID L,MOHR PETER,ROZEMA DAVID B,THUER WILMA,VALIS LINDA CHRISTINE,WAKEFIELD DARREN H
申请号：
ZA201205685
公开号：
ZA201205685B
申请日:
2012.07.27
申请国别(地区):
ZA
年份:
2013
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
