PETER MOHR,TORSTEN HOFFMANN,ERIC ARGIRIOS KITAS,PHILIPP HADWIGER,DAVID L. LEWIS,DAVID B. ROZEMA,WILMA THUER,LINDA CHRISTINE VALIS,DARREN H. WAKEFIELD
申请号：
PT11703711
公开号：
PT2539451E
申请日:
2011.02.18
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
