HADWIGER, PHILIPP,HOFFMANN, TORSTEN,KITAS, ERIC A.,LEWIS, DAVID L.,MOHR, PETER,ROZEMA, DAVID B.,THUER, WILMA,VALIS, LINDA CHRISTINE,WAKEFIELD, DARREN H.
申请号：
SG2012061073
公开号：
SG183374A1
申请日:
2011.02.18
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
