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POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO
专利权人:
发明人:
CHENG WEIJUN,WONG SO,ALMEIDA AARON M,ROZEMA DAVID B,BLOKHIN ANDREI V,CARLSON JEFFREY C
申请号:
IN201627003857
公开号:
IN201627003857A
申请日:
2016.02.03
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide amidobenzyl carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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