ROZEMA DAVID B,LEWIS DAVID L,WAKEFIELD DARREN H,KITAS ERIC,HADWIGER PHILIPP,WOLFF JON A,ROEHL INGO,MOHR PETER,HOFFMAN TORSTEN,JAHN HOFMANN KERSTIN,MUELLER HANS MARTIN,OTT GUENTHER,BLOKHIN ANDREI V,BEN
申请号：
IN4554/DELNP/2013
公开号：
IN2013DN04554A
申请日:
2013.05.22
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes . Targeted RNAi polynucleotides are administered together with co targeted me!ittm dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
