David B Rozema,David L Lewis,Darren Wakefield,Eric Kitas,Philipp Hadwiger,Jon Wolff,Ingo Röhl,Peter Mohr,Torsten Hoffmann,Kerstin Jahn-Hofmann,Hans Martin Mueller,Günther Ott,Andrei V Blokhin,Jonathan
申请号：
US13926380
公开号：
US09107957B2
申请日:
2013.06.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
