David B. Rozema,Darren H. Wakefield,Christine I. Wooddell,David L. Lewis
申请号：
US15200441
公开号：
US20170056472A1
申请日:
2016.07.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
