David B. Rozema;Jonathan D. Benson;Jon A. Wolff;H;Darren H. Wakefield;Peter Mohr;Eric A. Kitas;Kerstin Jahn-Hofmann;Jeffrey C. Carlson;David L. Lewis;Torsten Hoffman;Philipp Hadwiger;Andrei V. Blokhin
发明人:
David B. Rozema,Darren H. Wakefield,David L. Lewis,Jon A. Wolff,Andrei V. Blokhin,Jonathan D. Benson,Jeffrey C. Carlson,Philipp Hadwiger,Eric A. Kitas,Torsten Hoffman,Kerstin Jahn-Hofmann,Peter Mohr,H
申请号：
US13326433
公开号：
US20120165393A1
申请日:
2011.12.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
