THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;NOVARTIS AG
发明人:
BEATTY, GREGORY,ENGELS, BORIS,IDAMAKANTI, NEERAJA,JUNE, CARL H.,LOEW, ANDREAS,SONG, HUI-JUAN,WU, QILONG
申请号：
TW103144677
公开号：
TW201529850A
申请日:
2014.12.19
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of mesothelin. The invention also relates to chimeric antigen receptor (CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.本發明提供用於治療與間皮素表現有關之疾病的組合物及方法。本發明亦關於特異性針對間皮素之嵌合性抗原受體(CAR)、編碼其之載體及包含間皮素CAR之重組T細胞。本發明亦包括投與經遺傳修飾之T細胞的方法，該T細胞表現包含間皮素結合域之CAR。
