Boris Engels;Neeraja Idamakanti;Carl H. June;Gregory Beatty;Qilong Wu;Huijuan Song;Andreas Loew
发明人:
Gregory Beatty,Boris Engels,Neeraja Idamakanti,Carl H. June,Andreas Loew,Huijuan Song,Qilong Wu
申请号：
US15105082
公开号：
US20160311917A1
申请日:
2014.12.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor (CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.
