The Trustees of the University of Pennsylvania;Novartis AG
发明人:
Beatty, Gregory,Engels, Boris,Idamakanti, Neeraja,June, Carl H.,Loew, Andreas,Song, Huijuan,Wu, Qilong
申请号：
AU2014366047
公开号：
AU2014366047A1
申请日:
2014.12.19
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor(CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.
