Copmans, Alex Herman,Hoet, Jerome Albert Joseph,Willemsens, Albert Louis Anna,Couck, Wouter Louis J.,Van Dun, Joannes Petrus
申请号：
AU2010251910
公开号：
AU2010251910B2
申请日:
2010.05.27
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomaltriglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]-acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
