COPMANS, ALEX HERMAN,HOET, JEROME ALBERT JOSEPH,WILLEMSENS, ALBERT LOUIS ANNA,COUCK, WOUTER LOUIS J.,VAN DUN, JOANNES PETRUS
申请号：
CA2757702
公开号：
CA2757702C
申请日:
2010.05.27
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to a resolution process of (~)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP(microsomaltriglyceride transfer protein) inhibitor methyl(2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]-acetate and an epimerisation procedurefor racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
