Rozdzielanie (±)-fenylo[4-[4-[[[4'-(trifluorometylo)-2-bifenylilo]karbonylo]amino]fenylo]-1-piperydynylo] octanu metylu

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专利权人:

Janssen Pharmaceutica; N.V.

发明人:

COPMANS, ALEX HERMAN,HOET, JÉRÔME ALBERT JOSEPH,WILLEMSENS, ALBERT LOUIS ANNA,COUCK, WOUTER LOUIS J.,VAN DUN, JOANNES PETRUS

申请号：

PL10724047

公开号：

PL2435406T3

申请日:

2010.05.27

申请国别(地区):

PL

年份:

2013

代理人:

摘要：

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/